Ramesh Kumar Krishnan
Invivo Research Scientist
Haifa
Summary
A passionate and skilled biologist with a proven academic record of accomplishment and nine-plus years of experience in various biological research projects. An experienced researcher with a demonstrated history of working in the research industry and academic institutions.
Organized and dependable candidate successful at managing multiple priorities with a positive attitude. Willingness to take on added responsibilities to meet team goals.
Overview
11
11
years of professional experience
9
9
years of post-secondary education
Work History
Invivo Research Scientist & Study Director
Vivox - Experts in Invivo
Haifa
05.2022 - Current
- Leading multidisciplinary studies in various animal models - degenerative, metabolic, and oncological immunological diseases under GLP conditions.
- Proven ability to develop and implement creative solutions to complex problems.
- Responsible for developing, optimizing, troubleshooting, and validating in-vivo/in-vitro assays and experimental models.
- Responsible for writing study design proposals, study protocols, draft reports, and final reports.
- Responsible for the design, technical conduct, evaluation, and interpretation of non-clinical pharmaceutical investigations, in accordance with applicable regulatory guidelines, and contemporary scientific practice.
- Expertise in Invivo disease models, Invivo imaging, and FACS.
- Skilled at working independently and collaboratively in a team environment. Developed strong communication and organizational skills through working on group projects.
- Acted effectively as a team leader in group projects, delegating tasks and providing feedback.
- Identified issues, analyzed information and provided solutions to problems.
- Proven ability to learn quickly and adapt to new situations.
- Worked well in a team setting, providing support and guidance.
Short-term Post Doctoral Research Fellow
Ben-Gurion University of Negev
Be'ersheva
11.2021 - 04.2022
- Participated in team projects, demonstrating an ability to work collaboratively and effectively.
- Used strong analytical and problem-solving skills to develop effective solutions for challenging situations.
- Demonstrated strong organizational and time management skills while managing multiple projects.
- Worked flexible hours across night, weekend and holiday shifts.
- Completed paperwork, recognizing discrepancies and promptly addressing for resolution.
Doctoral Researcher
Ben-Gurion University of the Negev
Be'ersheva
10.2017 - 10.2021
- Worked on a combined in-vitro and in-vivo study of the assembly mechanism of actin and microtubule cytoskeleton in Drosophila bristles.
- Expertise in Confocal microscopy, Electron microscopy, and Drosophila genetics.
- Working knowledge in mammalian and Drosophila cell lines, CLEM, and SEM.
- Designed and executed CRISPR experiments.
- Performed laboratory analyses of samples using relevant apparatus and equipment. Wrote, proofread, and submitted research papers, reports, reviews, and summaries regarding Drosophila genetics.
- Coordinated and managed laboratory projects and experiments.
- Kept abreast of current industry, scientific and regulatory developments and issues.
- Participated in research projects by designing and executing experiments.
Research Associate
Medgenome
Bangalore
11.2015 - 10.2017
- Implemented Non-invasive prenatal testing (NIPT) lab protocols and performed NGS based NIPT assays.
- Prepared NGS libraries (whole genome, Exome, panels, etc.) and set up NGS runs.
- Skilled in sequencing, PCR, and Real-time PCR.
- Skilled in working in a regulated GLP/GMP environment.
- Validated incoming data to check information accuracy and integrity while independently locating and correcting concerns.
- Interpreted data analysis results to draw inferences and conclusions.
- Worked effectively across teams and independently.
Research Fellow
Thrombosis Research Institute
Bangalore
11.2012 - 11.2015
- Investigated the anti-atherosclerotic efficacy of the patented molecule.
- Evaluated the possibility of using mycobacterium as a delivery vector for the patented molecule.
- Used MiRNA approach to study the genes involved in atherosclerosis.
- Expertise in Confocal microscope, Cell culture, Molecular techniques, Immunohistochemistry techniques, FACS, and HPLC.
- Followed best practices and scientific protocol to reach defensible conclusions based on solid evidence.
- Edited papers for submission to prestigious academic and industry journals. Authored professional scientific papers for publishing in peer-reviewed journals.
- Performed scientific research on multiple projects.
Education
Ph.D. - Cell/Cellular and Molecular Biology
Ben-Gurion University of The Negev
Be'ersheva, Israel 10.2017 - 10.2021
Master of Science - Human/Medical Genetics, Biomedical Genetics
University of Madras
Chennai, India 06.2009 - 05.2011
Bachelor of Science - Biochemistry
PSG College of Arts And Science
Coimbatore, India 06.2006 - 05.2009
Skills
Analytical Skillsundefined
Accomplishments
Google scholar link - https://scholar.google.com/citations?user=vssjS-AAAAAJ&hl=en
1. Revisiting the role of beta-tubulin in Drosophila development: beta-tubulin60D is not an essential gene, and its
novel Pin1 allele has a tissue-specific dominant-negative impact.
Ramesh Kumar Krishnan, Naomi Halachmi, Raju Baskar, Bakhrat Anna, Raz Zarivach, Adi Salzberg, Uri Abdu.
Frontiers in cell and developmental biology. 2022.
2. PSMC1 variant causes a novel neurological syndrome.
Aharoni S, Proskorovski-Ohayon R, Krishnan RK, Yogev Y, Wormser O, Hadar N, Bakhrat A, Alshafee I, Gombosh
M, Agam N, Gradstein L, Shorer Z, Zarivach R, Eskin-Schwartz M, Abdu U, Birk OS. Clinical Genetics. 2022
Oct;102(4):324-332. doi: 10.1111/cge.14195. Epub 2022 Aug 3. PMID: 35861243; PMCID: PMC9541193.
3. Recapitulating Actin Module Organization in the Drosophila Oocyte Reveals New Roles for Bristle-Actin-
Modulating Proteins.
Krishnan RK, Baskar R, Anna B, Elia N, Boermel M, Bausch AR, Abdu U. International Journal of Molecular
Sciences. 2021; 22(8):4006.
4. Oral dosing with multi-antigenic construct induces atheroprotective immune tolerance to individual peptides in
mice.
Lakshmi Mundkur, Thiruvelselvan Ponnusamy, Sheena Philip, Lakshmi Narasimha Rao, Suryakant Biradar,
Vrushali Deshpande, Ramesh Kumar, Xinjie Lu, Vijay V Kakkar. International Journal of Cardiology. 2016.175
(2), 340-351.
5. Regulating inflammatory immune response to atherogenic antigens prevents the development and progression of
atherosclerosis in New Zealand white rabbits.
Sheena Philip, Thiruvelselvan Ponnusamy, Lakshmi Narasimha Rao, Suryakant Biradar, Ramesh Kumar, Vrushali
Deshpande, Xinjie Lu, Vijay V Kakkar, Lakshmi A Mundkur. Canadian Journal of Cardiology. 2016. 32 (8).
6. Tolerance to multiantigenic molecule expressing peptides from APOB100, HSP60, and outer membrane protein of
chlamydia pneumonia reduces markers of plaque instability and stabilizes advanced atherosclerosis in
APOBTM2SGY/LDLRTM1HER/J mice: OR008.
S Philip, T Ponnusamy, L Rao, R Krishnan, X Lu, V Deshpande, V Kakkar, L Mundkur. Journal of Thrombosis and
Haemostasis. 2015. 13,95-96.
7. Oral administration of recombinant Mycobacterium smegmatis expressing a tripeptide construct derived from
endogenous and microbial antigens prevents atherosclerosis in ApoE-/- mice.
Vrushali Deshpande, Rameshkumar Krishnan (Equal contribution), Sheena Philip, Ildiko Faludi, Thiruvelselvan
Ponnusamy, Lakshmi Narasimha Rao Thota, Valeria Endresz, Xinjie Lu, Vijay V Kakkar, Lakshmi A Mundkur.
Cardiovascular therapeutics. 2014. 34 (5), 314-324.
Timeline
Invivo Research Scientist & Study Director
Vivox - Experts in Invivo
05.2022 - Current
Short-term Post Doctoral Research Fellow
Ben-Gurion University of Negev
11.2021 - 04.2022
Ph.D. - Cell/Cellular and Molecular Biology
Ben-Gurion University of The Negev
10.2017 - 10.2021
Doctoral Researcher
Ben-Gurion University of the Negev
10.2017 - 10.2021
Research Associate
Medgenome
11.2015 - 10.2017
Research Fellow
Thrombosis Research Institute
11.2012 - 11.2015
Master of Science - Human/Medical Genetics, Biomedical Genetics
University of Madras
06.2009 - 05.2011
Bachelor of Science - Biochemistry
PSG College of Arts And Science
06.2006 - 05.2009
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